Department of Molecular Biosciences, The Wenner-Gren Institute

Phone: +468162000
Fax: +468159837
Address:
Svante Arrheniusväg 20 C
106 91
Sweden


Department projects

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The gut-immune crosstalk and its consequences for immune function and allergy development
01/01/2017 - 31/12/2021

In the gut, the microbiota provides the host with essential functions related to the digestive system, but gut microbes also influence the immune system, with possible implications for the development of immune-mediated disease.

This translational project spans from huma...


Innate immunity, nematodes and wound responses
01/01/2017 - 31/12/2020

We study the immune response against nematodes using insects as hosts.
Insect pathogenic nematodes (EPNs) enter the body via epithelial
surfaces creating wounds, as do several human pathogenic nematodes. In
line with this mode of infection, the response against nematodes...


Applying of single cell technology to bridge the knowledge gap in malaria transmission and mosquito stages
01/01/2017 - 31/12/2020

The complex lifecycle of Plasmodium falciparum includes transitioning
between a human host and a mosquito vector. Sexual stage commitment and
gametocyte development are events that enable disease transmission and
lead to sexual replication inside the anopheline mosquito,...


Mechanisms of regulated proteolysis in bacterial cell cycle control
01/01/2017 - 31/12/2020

Intracellular proteolysis is a fundamental cellular process. Despite a
good understanding of the biochemistry of cellular proteases, the
mechanisms that dictate when and in which cellular context specific
target proteins are degraded remain poorly understood. Previous wo...


European Joint Programme for the Integration of Radiation Protection Research
01/06/2015 - 31/05/2020

The proposed European Concerted Programme on Radiation Protection Research (acronym: CONCERT) aims to contribute to the sustainable integration of European and national research programmes in radiation protection. It will do so by focusing resources and efforts in five key dir...


Molecular mechanisms of interactions between human cells and bacteria.
01/01/2017 - 31/12/2019
The
purpose is to increase our understanding of how bacteria exploit the
host cells, interact with the normal flora and overcome host cell
defences. We study clinically important bacterial pathogens that cause
life-threatening diseases, such as sepsis, meningitis, ne...

Evolution, adaptive regulation, and functional impact of gene silencing by hairpin-RNA derived endogenous small interfering RNA pathways
01/01/2016 - 31/12/2019

As a major class of regulatory RNAs, small RNAs including microRNAs
(miRNAs) and endogenous interfering RNAs (endo-siRNAs), have been of
major research focus for the last decade. Recently I, with
collaborators, characterized a new form of endo-siRNAs called hairpin
RNA...


The exosome: roles in chromatin regulation and DNA repair
01/01/2016 - 31/12/2019

The packaging of DNA into chromatin has profound effects on gene expression, genome stability and transmission of genetic information. Eukaryotic genomes are transcribed to a much larger extent than previously anticipated, and non-coding RNAs (ncRNAs) play a variety of functio...


Molecular studies of DNA repair and mating-type switching in budding yeasts
01/01/2016 - 31/12/2019

Transposable elements (TEs) have had immense impact on genomic evolution. Understanding the mechanisms leading to genomic change is central to our understanding of gene regulation, genetic disease and evolution. Full appreciation of these processes is not possible without comp...


Alternative β-adrenergic signaling: an innovative way to treat type II diabetes
01/01/2016 - 31/12/2019

We have discovered a physiological pathway, leading to glucose uptake, that we believe can be used to treat type II diabetes. The pathway works independently of insulin and is reliant on stimulation of adrenergic receptors (AR) resulting in increased glucose uptake in skeletal...



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Last updated on 2017-12-06 at 09:44