Department of Molecular Biosciences, The Wenner-Gren Institute

In the gut, the microbiota provides the host with essential functions related to the digestive system, but gut microbes also influence the immune system, with possible implications for the development of immune-mediated disease.

This translational project spans from huma...

We study the immune response against nematodes using insects as hosts.
Insect pathogenic nematodes (EPNs) enter the body via epithelial
surfaces creating wounds, as do several human pathogenic nematodes. In
line with this mode of infection, the response against nematodes...

The complex lifecycle of Plasmodium falciparum includes transitioning
between a human host and a mosquito vector. Sexual stage commitment and
gametocyte development are events that enable disease transmission and
lead to sexual replication inside the anopheline mosquito,...

Intracellular proteolysis is a fundamental cellular process. Despite a
good understanding of the biochemistry of cellular proteases, the
mechanisms that dictate when and in which cellular context specific
target proteins are degraded remain poorly understood. Previous wo...

The proposed European Concerted Programme on Radiation Protection Research (acronym: CONCERT) aims to contribute to the sustainable integration of European and national research programmes in radiation protection. It will do so by focusing resources and efforts in five key dir...

As a major class of regulatory RNAs, small RNAs including microRNAs
(miRNAs) and endogenous interfering RNAs (endo-siRNAs), have been of
major research focus for the last decade. Recently I, with
collaborators, characterized a new form of endo-siRNAs called hairpin
RNA...

The packaging of DNA into chromatin has profound effects on gene expression, genome stability and transmission of genetic information. Eukaryotic genomes are transcribed to a much larger extent than previously anticipated, and non-coding RNAs (ncRNAs) play a variety of functio...

Transposable elements (TEs) have had immense impact on genomic evolution. Understanding the mechanisms leading to genomic change is central to our understanding of gene regulation, genetic disease and evolution. Full appreciation of these processes is not possible without comp...

We have discovered a physiological pathway, leading to glucose uptake, that we believe can be used to treat type II diabetes. The pathway works independently of insulin and is reliant on stimulation of adrenergic receptors (AR) resulting in increased glucose uptake in skeletal...