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Innate immunity, nematodes and wound responses01/01/2017 - 31/12/2020 We study the immune response against nematodes using insects as hosts. Insect pathogenic nematodes (EPNs) enter the body via epithelial surfaces creating wounds, as do several human pathogenic nematodes. In line with this mode of infection, the response against nematodes... |
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Mechanisms of regulated proteolysis in bacterial cell cycle control01/01/2017 - 31/12/2020 Intracellular proteolysis is a fundamental cellular process. Despite a good understanding of the biochemistry of cellular proteases, the mechanisms that dictate when and in which cellular context specific target proteins are degraded remain poorly understood. Previous wo... |
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Molecular mechanisms of interactions between human cells and bacteria.01/01/2017 - 31/12/2019 The purpose is to increase our understanding of how bacteria exploit the host cells, interact with the normal flora and overcome host cell defences. We study clinically important bacterial pathogens that cause life-threatening diseases, such as sepsis, meningitis, ne... |
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The exosome: roles in chromatin regulation and DNA repair01/01/2016 - 31/12/2019 The packaging of DNA into chromatin has profound effects on gene expression, genome stability and transmission of genetic information. Eukaryotic genomes are transcribed to a much larger extent than previously anticipated, and non-coding RNAs (ncRNAs) play a variety of functio... |
Molecular studies of DNA repair and mating-type switching in budding yeasts01/01/2016 - 31/12/2019 Transposable elements (TEs) have had immense impact on genomic evolution. Understanding the mechanisms leading to genomic change is central to our understanding of gene regulation, genetic disease and evolution. Full appreciation of these processes is not possible without comp... |
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