Department of Biochemistry and Biophysics

Phone: +468162000
Fax: +468153679
Svante Arrhenius väg 16
106 91 Stockholm

Department projects

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High-valent protein-coordinated catalytic metal sites: Geometric and Electronic ARchitecture
01/06/2017 - 31/05/2022

It is estimated that almost half of all enzymes utilize metal cofactors for their function, for example the respiratory complexes and the oxygen-evolving photosystem II, the most fundamental requirements for aerobic life as we know it. If we could mimic nature’s use of metals ...

Towards a complete map of the transmembrane proteome in Yeast and E.Coli
01/01/2017 - 31/12/2020

A complete structural knowledge of all proteins and their interactions in a ceulular compartment would provide an unprecedented detailed picture. Using this model it would be possible not only to ask what functions could occur but a...

Regulation of mitochondrial expression
01/10/2016 - 30/09/2020

Mitochondria are essential organelles found in every eukaryotic cell, required to convert food into usable energy. The mitochondrial oxidative phosphorylation (OXPHOS) system, which produces the majority of cellular energy in the form of ATP, is controlled by two distinct geno...

New Diagnostics for Infectious Diseases
01/03/2016 - 29/02/2020

Infectious diseases are a major burden to public health and the global economy, not in the least due to antimicrobial resistance. Rapid point of care (POC) in vitro diagnostics (IVD) are key tools in the effective clinical management of patients with infectious diseases. Yet t...

Structure and Function of Sodium/Proton Antiporters
01/01/2014 - 31/12/2019
Laddade molekyler, så kallade joner, förföyttas över cellmembranet på två olika sätt. Den ena metoden som etablerades redan på 60-talet, innebär att en jon passerar över membranet genom kanaler. Det andra sättet för ...

Proton transfer and nitric oxide reduction in heme-copper oxidases
01/01/2016 - 31/12/2019

Bacterial NO-reductases (NOR) are integral membrane proteins that reduce the toxic gas nitric oxide (NO) to dinitrous oxide (N2O) (2NO+2e-+2H+->N2O+H2O). NORs are divergent members of the super-family of oxygen-reducing, proton pumping, heme-copper oxidases (HCuOs), to which t...

Structural dynamics and allosteric regulation of mammalian
channels and transporters
01/01/2015 - 31/12/2019
Jonkanaler och transportörer är membranbundna proteiner som transporterar joner och andra molekyler över cell-­‐membranet. De är avgörande för att hålla jon-­‐ och vätskebalansen inuti cellerna och är speciellt viktiga i nervc...

Exploring ribonucleotide reductase as a target to combat bacterial infections
01/01/2017 - 31/12/2019

We will search for novel antibiotics against human pathogens with the enzyme ribonucleotide reductase (RNR) as a target. RNR is essential to all free-living organisms and provides building blocks for DNA ...

Co-translational folding of water-soluble and membrane proteins
01/01/2015 - 31/12/2019
Ungefär 30% av alla proteiner som uttrycks i en cell är membranproteiner. Trots membranproteinernas stora betydelse, både inom den grundläggande biologin och för läkemedelsutveckling, saknas fortfarande viktig kunskap om hur de tillverkas, sätt...

Single-particle cryo-EM studies of membrane protein biogenesis and structure
01/01/2015 - 31/12/2019
Ungefär 30% av alla proteiner i en typisk cell är integrerade i cellens lipidmembran. Dessa s.k. membranproteiner sköter en mängd viktiga funktioner i cellen: de ansvarar för transport av joner, molekyler och makromolekyler in i och ut ur cellen, de plock...


Last updated on 2017-22-08 at 06:52