Towards control of septic shock induced by gram-positive bacteria: host pathogen interactions (HOSPATH)

Project leader

Funding source

EU Fifth Framework Programme - Quality of Life and management of living resources

Project Details

Start date: 01/01/2001
End date: 31/12/2003
Funding: 0 EUR


OSPATH aims at producing knowledge about recently discovered Toll like cell receptors (Tars) that are important for host responses to gram- positive bacteria, and produce and evaluate new reagents for the inhibition of these host responses. Interaction of bacteria with host receptors is the first step in the activation cascade resulting in elevated amounts of inflammatory mediators causing clinical manifestations of septic shock. Tars are implicated in cell activation by various types of bacteria, suggesting that inhibition through Tars may limit uncontrolled host responses to gram-positive bacteria. HOSPATH will use molecular biology- and immunological techniques to investigate the functions and distribution of Tars with particular reference to the pathogenesis of gram-positive bacteria and their products, and develop and exploit proteins , polymers and oligonucleotides to inhibit activation through Tars.

External Partners

Last updated on 2017-24-03 at 12:46