Integrating Epidemiology and Experimental Biology to Improve Risk Assessment of
Exposure to Mixtures of Endocrine Disruptive Compounds

Project leader

Funding source

EU Horizon 2020

Project Details

Start date: 01/05/2015
End date: 30/04/2019
Funding: 6223330 EUR


A large body of evidence supports associations between exposure to anthropogenic chemicals and endocrinedisruptive effects, leading to disorders in humans and wildlife. Based on the scientific documentation it is beyonddoubt that endocrine disrupting chemicals (EDCs) are of concern and need to be handled according to the risksthey pose, as single chemicals or as mixtures. To develop chemical risk assessment to respond to these concerns,there is an urgent need to improve our understanding of the mechanisms and health effects of EDCs, in particularin mixtures. This will require selection, refinement and development of tools for assessment of EDC mixtures tobring current risk assessment procedures to a level where they can support risk management. This project is designedto promote the use of safe chemicals for the next generation. EDC-MixRisk aims to meet the societal need forimproved decision-making regarding human exposure risks to mixtures of EDCs. EDC-MixRisk will determine risksfor multiple adverse health outcomes based on molecular mechanisms involved after early life exposure to EDCmixtures. The task is approached through interdisciplinary cooperation between experts in epidemiology, experimentaltoxicology and molecular biology, and risk assessment. The value of this combined research effort is: i) Identificationof EDC mixtures that are associated with multiple adverse health outcomes in three health domains (growth andmetabolism, neurodevelopment and sexual development) in epidemiology; ii) Identification of molecular mechanismsand pathways underlying the associations between exposure and adverse health outcomes by the use and developmentof state-of-the-art experimental models and iii) Development of a transparent and systematic framework in riskassessment for integrating epidemiological and experimental research to facilitate the assessment of risk and societalimpact, thus promoting better risk management for EDCs and their mixtures.

External Partners

Last updated on 2018-11-12 at 10:48