Towards discovery of antifungal compounds from Tanzanian medicinal plants for managing opportunistic infections among HIV/AIDS patients: An alternative strategy to prolong life


Project leader


Funding source

Swedish Research Council - Vetenskapsrådet (VR)


Project Details

Start date: 01/01/2014
End date: 31/12/2016
Funding: 3035000 SEK


Description

This collaborative research aims to develop new antifungals from Tanzanian plants to serve as an alternative strategy for combating drug resistance and fungal infections among HIV/AIDS patients. Worldwide, the problem of HIV infection is complicated by the occurrence of many infections caused by bacteria and fungi, increasing the number of HIV/AIDS cases that has raised the demand for medical care and hence created a burden to the available limited health budgets. This necessitates continued effort to search for natural medicines of plant origin. The targeted plant species are those claimed traditionally to infection diseases. The project will involve ethnomedical survey, extracts preparation, bio-guided isolation of active ingredients and standardization of herbal drugs, to be done at ITM-MUHAS. Further purification and structural determination of isolated active compounds which requires access to preparative HPLC systems and advanced Spectroscopic facilities, will be done at the University of Stockholm (SU). Furthermore, synthesis of active molecules and their analogues (SU), will give better understanding of the structure activity relationship (SAR) of the target molecules.

Last updated on 2017-31-03 at 12:57