Analysis of DNA damage complexity and repair in cells exposed to a mixed beam


Project leader


Funding source

Swedish Radiation Safety Authority - Strålsäkerhetsmyndigheten


Project Details

Start date: 01/10/2013
End date: 30/06/2014
Funding: 498000 SEK


Description

A particular problem of radiation protection is exposure of people to mixed beams of high and low LET radiation in the environment and in medicine. The long-term cancer risks of this exposure are not understood. Of particular interest is the question if high and low LET radiations, when given together, act in an additive (meaning no interaction) or synergistic (meaning a positive interaction) manner.

Work of the present project will focus on studying the question if exposure to mixed beams leads to the formation of clustered damage beyond the level expected from an additive action of both radiation types. Clustered DNA damage poses serious problems for the DNA repair machinery and error-prone repair of DNA damage is associated with cancer induction. Therefore, increased damage complexity following exposure to mixed beams will suggest a higher than expected risk of cancer induction. In this way, the goal of the project is highly related to the problem of protecting people from the stochastic effects of ionising radiation.


Last updated on 2017-24-03 at 12:47