QSARs and other non-testing instruments to reduce animal tests: From science to regulatory decisions


Funding source

Swedish Research Council - Vetenskapsrådet (VR)


Project Details

Start date: 01/01/2009
End date: 31/12/2011
Funding: 2000000


Description

Within the new European legislation for industrial chemicals - REACH - regulatory use of data obtained from QSAR models and other "non-testing" methods have been introduced as priority setting tools. These are methods that make no use of experimental animals. A valid and scientifically justified priority setting tool has the potential to significantly reduce the need for animal testing within REACH by limiting in vivo testing to the (low-volume) substances of highest concern. The overall purpose of this project is to reach in-depth understanding in a regulatory framework of in silico instruments relative to in vitro and in vivo testing and to provide scientific input to the process of identifying how QSARs and other non testing methods could be used to reduce, replace and refine in vivo testing within REACH. In particular, we will develop a database with QSAR, non-testing, in vitro and in vivo data and use this database to compare the outcome of data generated by the different approaches. In this way we will be able to identify strengths and weaknesses with QSAR and other non-testing methods as priority-setting tools and provide recommendations for their regulatory use, taking e.g. animal welfare, monetary costs, variation in data, and criteria for risk assessment into account.

Last updated on 2017-31-03 at 12:57