An Hbp autotransporter based platform for the identification of epitopes and their surface display in live vaccines


Project leader


Funding source

Swedish Research Council - Vetenskapsrådet (VR)


Project Details

Start date: 01/01/2010
End date: 31/12/2011
Funding: 1200000 SEK


Description

The rise of antibiotic resistant pathogens and the increasing danger of pandemics are prime reasons for the rapidly changing human health care landscape. As a consequence, there is an urgent need for platforms allowing the rapid identification of epitopes and large-scale production of multivalent vaccines in a fast and cost-effective way. Aim of this project is to use the Hbp autotransporter system from Escherichia coli to develop a versatile and low cost cell surface display platform for -i- the identification of epitopes and -ii- their expression on the cell surface in live bacterial vector systems for oral vaccination.

Last updated on 2017-31-03 at 12:57