Peptidoglycan recognition proteins; innate immunity proteins conserved from insects to man


Project leader


Funding source

Swedish Research Council - Vetenskapsrådet (VR)


Project Details

Start date: 01/01/2006
End date: 31/12/2008
Funding: 1500000 SEK


Description

I want to study innate immune responses against bacteria and fungi. In Drosophila the Toll and the Imd pathways can discriminate between different microbes and mount an appropriate response to eliminate the intruder. The present application is about the proteins responsible for this discriminatory recognition, the peptidoglycan recognition proteins (PGRPs). Peptidoglycan recognition proteins are well conserved from insects to man. – So far only peptidoglycan has been convincingly shown to be a ligand to PGRP. We want to find the rationale behind peptidoglycan being a pattern that is recognized. Are there other ligands for PGRPs or are there other receptors for non-peptidoglycan microbial signature molecules? – Apart from the PGRP-ligand interactions we want to study the PGRP-LC dimer formation following ligand binding. Is there a conformational change that triggers the activation signal? What is the role of the PGRP-LCa adaptor for this activation? – We also plan to better characterize the regulating roles played by PGRP-LF and the enzymatic PGRPs to curb the peptidoglycan-induced response.

Last updated on 2017-31-03 at 12:58