How important is dust ingestion as an exposure pathway for brominated flame retardants (BFRs) and perfluorinated compounds (PFCs) in toddlers (11 months-of-age) and their mothers?


Project leader


Co-Investigators


Funding source

Formas - The Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning


Project Details

Start date: 01/01/2009
End date: 31/12/2011
Funding: 3100000 SEK


Description

Studies of PBDEs, PFOS and PFOA in humans have shown more highly skewed distributions than for PCBs and dioxins, where diet is the major exposure route. Dust ingestion is suggested to be an additional exposure route for BFRs and PFCs. The importance of dust ingestion has only been estimated, but could be substantial, 50-80% of contaminant intake in some scenarios for toddlers. The aim of this project is therefore to quantify the relationships between external exposure to BFRs and PFCs from ingestion of indoor dust as well as dietary intake and internal concentrations in primiparous women (blood and milk) and their young children (blood) and to explore the feasibility of using feces as a non-invasive method for measuring these compounds in toddlers. Concentrations of tetra-decaBDEs, HBCD, PFOS and PFOA will be analyzed in serum and milk from 60 women in Uppsala, in dust samples from their homes, and in serum and feces from their children at 11 months of age. Archived Swedish food basket samples from 2005 and some processed baby foods will be analyzed to complement missing data in order to estimate dietary intake of all target compounds. Based on BFR and PFC levels in food and dust for mothers, and breast milk, baby food and dust for toddlers, the exposure from the different pathways will be quantified and compared to body burdens derived from the measured internal concentrations using an existing non-steady state human bioaccumulation model.


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Last updated on 2017-24-03 at 12:56