Dietary lipids as risk factors in development. mechanistic issues (DLARFID)

Project leader

Funding source

EU Fifth Framework Programme - Quality of Life and management of living resources

Project Details

Start date: 01/01/2002
End date: 31/12/2004
Funding: 2218660 EUR


Beta-carotene, the source of the lipid soluble Vita and retinue acid in humans was recommended for the prevention of arteriosclerosis and cancer development. Unexpectedly , the recent three multimembers, randomised human trials revealed the weak protective effect against the increased incidence of myocardial infarction, and morbidity/mortality due to the lung cancer. Since the b-carotene is commonly used as the food colorant , the influence of its metabolites together with fatty acids (FA) derivatives (known regulators of nuclear receptors) will be investigated in the healthy and cancer human and animal cells. The possible involvement of the new classes of proteins and genes (gene clusters) will be followed by the most modern methods to determine the early markers of pathology which would serve as the new diagnostic measure for the cancer hazard determination and understanding of the food and consumer safety.

External Partners

Last updated on 2017-24-03 at 12:48