ATP-dependent Chromatin Remodelling Complexes in Transcription and other nuclear processes


Project leader


Funding source

Swedish Research Council - Vetenskapsrådet (VR)


Project Details

Start date: 01/01/2007
End date: 31/12/2009
Funding: 1200000 SEK


Description

Chromatin plays an important role in nuclear processes, as it constitutes a barrier for factors invovled in processes that need to gain access to DNA. Each cell has several proteins complexes that change the chromatin structure and play roles in gene regulation, replication, DNA repair, recombination, and in the maintenance of hte chromatin structure. This project aims at understanding how nuclear processes, in particular transcription, is regulated and how different processes are coordinated in a chromatin context. We have found a novel complex, B-WICH, which is involved in ribosomal RNA synthesis, probably even the activator of rRNA transcription, and we will now try to understand its mechanisms of action and how it plays a role in the regulation of these genes. These aspects are important for the understanding of cell growth, a process that has gain importance in cancer and diabetes research. Some B-WICH is also found on pol II genes associated with another group of ATP-dependent chromatin remodellers, the SWI/SNF complexes. One important question is how the complex formation is coordinated between these processes. Defects in these activities result in diseases, such as developmental disorders and cancer. To understand how cells overcome the chromatin barrier and how chromatin remodelling complexes work gives us important insights into how eukaryotic cells work.

Last updated on 2017-31-03 at 12:58