Chemistry of Nucleoside Phosphonates and Related Compounds of Biological Significance


Project leader


Funding source

Swedish Research Council - Vetenskapsrådet (VR)


Project Details

Start date: 01/01/2008
End date: 31/12/2013
Funding: 1200000 SEK


Description

Located at the crossroad of various bioinformation exchange pathways, phosphorus compounds play a key role in living organisms as carriers of genetic information, important signalling, regulatory, and structural compounds. Due to this pivotal biochemical role, numerous phosphate analogues exhibit a potent biological activity which constitutes a strong rationale for their increasingly growing applications, inter alia, as agrochemicals and medicinal compounds. To maximise the desire biological effect and to minimise potential cytotoxic effects, chemical properties of these compounds have to be very precisely designed. In this respect, modifications at the phosphorus centre, additionally controlled by stereochemical factors, may provide the necessary tuning in interactions with enzymes. To address these most fundamental chemical questions of the contemporary rational drug design, we propose eight comprehensive projects: (1) Basic studies on the palladium-catalyzed the P-C bond formation. (2) Studies on the reactions of H-phosphonates with S-nucleophiles. (3) Stereospecific synthesis of P-chiral phosphorus compounds. (4) Synthesis of H-phosphonate derivatives under the Mitsunobu coupling conditions. (5) Synthesis of oligonucleotide analogues for biomedical intervention. (6) Development of new artificial nucleases. (7) Phosphorylated lipid mediators as potential drugs and drug delivery systems. (8) Development of tools for supramolecular chemistry and nanotechnology.

Last updated on 2017-31-03 at 12:58