Nutrient regulated gene expression II

Project leader

Funding source

Swedish Research Council - Vetenskapsrådet (VR)

Project Details

Start date: 01/01/2009
End date: 31/12/2011
Funding: 1800000 SEK


Nutrient uptake is essential for life. We study the mechanisms of signal transduction that enable yeast cells to assess the availability of amino acids in their growth environment. The overall goal has been to use this model system to obtain precise and detailed mechanistic understanding of fundamental signaling processes to facilitate studies in other organisms. The key signaling events that transmit signals from the plasma membrane to the promoters of responsive genes have been defined, and these studies have illuminated several novel aspects of eukaryotic-specific gene regulation, including receptor activated proteolysis and transcriptional repression by integral components of the inner nuclear membrane. The proposed experiments are designed to clarify the roles of the individual components of the amino acid induced signaling pathway and to fill remaining gaps in our understanding.

Last updated on 2017-31-03 at 12:58