Regulators of epithelial wound healing in Drosophila


Project leader


Funding source

Swedish Research Council - Vetenskapsrådet (VR)


Project Details

Start date: 01/01/2010
End date: 31/12/2012
Funding: 2400000 SEK


Description

Wound healing and tissue repair is a fundamental property of multicellular organisms ranging from sponges to humans. Despite the medical importance of wound regeneration, progress in defining the signaling mechanisms initiating and orchestrating wound responses has been slow due to the complexity and redundancy of the vertebrate models. In Drosophila, the epidermal barrier is a single epithelial cell layer covered by a rigid exoskeleton. The molecular analysis of embryonic wound healing has revealed that some of the essential steps in the process are conserved from flies to man. We have developed quantitative live-imaging assays to investigate epithelial regeneration in genetically tractable Drosophila embryos. Using bioinformatics and molecular genetics we have identified and characterized Stitcher, the first epithelial receptor selectively required for embryonic wound closure. The objectives of this proposal are: 1) Identify the genes required for epithelial wound healing in Drosophila. 2) Decipher the signaling network of the Receptor Tyrosine Kinase, Stitcher. 3) Elucidate the molecular roles of wound healing effectors in vitro and in vivo. One important goal of wound healing research is to find ways to speed or alter the healing process. We aim to understand the molecular details of wound responses and thereby aid the development of therapeutic interventions that speed up or inhibit wound regeneration.

Last updated on 2017-31-03 at 12:58