Higher-Order Olfactory Functions – Genetic Influences and Neuroanatomical Correlates

Project leader

Funding source

Swedish Research Council - Vetenskapsrådet (VR)

Project Details

Start date: 01/01/2006
End date: 31/12/2008
Funding: 1215000 SEK


The overall goals of the present application are to increase our understanding of higher order olfactory functioning and associations with genetic variation and volumetric measures of brain structures (e.g., hippocampus, enthorinal cortex). The research is based on two longitudinal prospective studies on aging and memory: The Betula project and the The Swedish National study of Aging and Research in Kungsholmen (the SNACK project). Both studies carry an interdisciplinary approach covering several medical, social and psychological fields. The projects comprise DNA extraction and genotyping in combination with extensive cognitive testing, including memory for olfactory information. Previous research suggests large individual variations in olfactory functioning, which appears in part, be related to genetic heterogeneity. The present research will address associations between a number of specified genes known to affect cognitive functioning (i.e., COMT, ApoE, BDNF) with a set of olfactory cognitive tasks (i.e., episodic odor memory, odor identification). Of particular interest in the project is to combine volumetric measures and genetic status with psychophysical measures on olfactory function.

Last updated on 2017-31-03 at 12:58