Chemical Biology with Carbohydrates - Approaches Towards Potential Drugs and Vaccines Against Infectious Diseases

Funding source

Swedish Research Council - Vetenskapsrådet (VR)

Project Details

Start date: 01/01/2007
End date: 31/12/2009
Funding: 1650000 SEK


The specific goals of this application are to: - Investigate in detail the binding of bacteria, E. coli and H. pylori, to human carbohydrate receptors by the use of synthetic oligosaccharides, analogues, dendrimers and conjugates and to design and synthesise compounds that will function as inhibitors of the binding and thus as antibiotics; - Investigate the specificity and biological role of the human lectins Calreticulin/Calnexin and Galectins by use of synthetic oligosaccharides and analogues, dendrimers and conjugates thereof; - Investigate in detail the biosynthesis of mycothiol, a low molecular mass thiol essential for the growth of M. tuberculosis in culture, and to design and synthesise possible inhibitors for selected enzymes in the biosynthetic pathway to develop new types of antibiotics against tuberculosis; - Synthesise structures corresponding to the capsular polysaccharides of N. meningitidis serogroup A, C. neoformans and V. cholerae O-139 and to the lipopolysaccharide of H. influenzae and N. meningitidis to evaluate their immunological properties. After conjugation to selected carrier proteins these glycoconjugates will be used in immunization experiments to, in collaboration with immunologists and vaccine companies, develop vaccines against diseases caused by these microbes; - Develop new methodology for glycosylation reactions, protecting group manipulations and conjugations.

Last updated on 2017-31-03 at 12:58