ELOVL-regulation of VLCFA synthesis in mammals


Project leader


Funding source

Swedish Research Council - Vetenskapsrådet (VR)


Project Details

Start date: 01/01/2009
End date: 31/12/2011
Funding: 1500000 SEK


Description

The ability to synthesize very long chain fatty acids (VLCFA) is a ubiquitous system found in most cell types. They are important constituents of sphingolipids, glycerophospholipids, triglycerides, sterol- and wax-esters. Depending on their chain length and degree of unsaturation, they contribute to membrane fluidity and other chemical properties of the cells as well as signaling functions. Up to date, there are hardly any reports on how the levels of VLCFA are controlled in any organism neither on the significance of endogenous synthesized VLCFA vs. VLCFA taken up from the diet. My prospects are: a) to identify and explain the regulation of VLCFA synthesis in mammalian cells, b) to identify the target molecules for these VLCFA and c) identify the cellular and physiological significance of these lipid molecules. To achieve this we will focus on the regulation and physiological role of the two VLCFA elongases ELOVL2 and ELOVL3, which are controlling de novo synthesis of poly-unsaturated and saturated/monounsaturated VLCFA, respectively. To facilitate this we have obtained Elovl2 and Elovl3-ablated mice, which we currently are analyzing.

Last updated on 2017-31-03 at 12:58

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