Evolution, variation, structure and interactions of repeat domain containing proteins


Project leader


Funding source

Swedish Research Council - Vetenskapsrådet (VR)


Project Details

Start date: 01/01/2011
End date: 31/12/2013
Funding: 2400000 SEK


Description

More than 70% of the proteins in the human proteome consist of multiple domains and about 17% of the proteins contain repeated domains. Understanding their structure, function, and evolution of repeated proteins may be important for understanding the complexity of the human genome and genetic diseases in particular given the recent observation that copy number variations are more abundant than variations due to single nucleotide polymorphism. In addition, since regulation and signaling are central tasks of repeat containing proteins, it is not surprising that many of them have been implicated as cancer genes. In this proposal we aim to use extend our studies of repeat domain containing proteins. The proposal is divided into three sections. In the first we will utilize the flood of genomic sequence data coming from next generation sequencing projects to increase our understanding of evolution and variation of repeat containing proteins. In the second proposal we will experimentally study interactions of two types of repeat containing proteins, proteins with TPR and nebulin domains. In the third part we will develop improved method to determine the structure of repeat domains, repeat domain containing proteins and of molecular complexes involving these proteins. Finally, towards the end of this project period generate models for all four human nebulin containing proteins when bound to actin.

Last updated on 2017-31-03 at 12:59