A real-time monitoring system of airborne norovirus (NOROSENSOR)


Project leader


Funding source

EU Seventh Framework Programme


Project Details

Start date: 01/12/2013
End date: 30/11/2016
Funding: 4434496 EUR


Description

Gastroenteritis, caused by the airborne Norovirus, is the third most deadly infectious disease worldwide, infecting ~4% of the population annually, worldwide, and has related costs measured in billions € annually in the EU alone. Today, detection of airborne viruses can only be done in retrospect in the laboratory, which severely limits the ability to rapidly react and limit the spread of an outbreak. The NOROSENSOR consortium will address this problem by developing the first of its kind, real-time sensor for airborne viruses, with particular focus on the NoV. Because the virus concentration in air can be very low, and because rapid and efficient virus trapping and concentration methods have been missing, no solution exists today. The NOROSENSOR project will fill this important need by integrating a number of recently developed, highly powerful technologies:

• Novel nanobiotechnology: nanobead enhanced rolling circle amplification (nano-RCA), engineered synthetic DNA aptamers, and proximity ligation assays (PLA)

• First ever airborne nanoparticle manipulation: capturing, filtering and up-concentration of viruses using acoustophoresis and electrostatic precipitation.

with beyond state-of-the-art:

• Ultra-sensitive QCM mass-sensitive transducers and electronics.

• Novel Off-stoichiometry Thiol-Ene-Epoxies (OSTE) polymers for cartridge and reagent storage on-chip.

The consortium consist of six of the highest ranked European Universities, each experts in their research area, two SMEs

providing a unique expertise in their core business areas, and a large multinational industry in infection control technology.


External Partners


Last updated on 2018-18-12 at 14:29