Redox control of the actin microfilament system in normal and malignant cells


Project leader


Funding source

Swedish Research Council - Vetenskapsrådet (VR)


Project Details

Start date: 02/01/2008
End date: 30/12/2009
Funding: 650000 SEK


Description

Redox control of the actin microfilament system in cell motility and migration and its perturbations in pathophysiology inclulding cancer is an emerging field of research. Actins are highly conserved eukaryotic proteins existing in different isoforms. They form an essential part of chemo-mechanical transduction systems in muscle as well as in non-muscle cells, where they, together with actin-binding proteins, generate force for various activities involved in translocation and cell shape change. The beta- and gamma-actin isoforms are amongst the most abundant proteins in many cell types, pivotal in maintaining and mediating the infrastructure of the intracellular matrix. The constant and rapid reorganization of the non-muscle actin microfilament (MF)-system during cell motility and migration, mitogenesis, and phagocytosis depends on nucleation, elongation, and depolymerization of actin filaments as elementary processes. Crucially, transmembrane signaling, in most cases, is directly linked to the submembraneous, highly concentrated and well organized weave of actin microfilaments, and there is evidence that not only actin, but also the actin-interacting proteins profilin and tropomyosin are direct targets for oxidative modification in vivo.


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Last updated on 2017-31-03 at 12:58