NMR investigations of membrane-protein interactions


Project leader


Funding source

Swedish Research Council - Vetenskapsrådet (VR)


Project Details

Start date: 01/01/2008
End date: 31/12/2010
Funding: 1800000 SEK


Description

Many important processes in life take place in or around the cell membranes. Membranes and membrane proteins constitute a challenging field of research, and despite the fact that maybe more than 30% of known genomes code for membrane proteins, very little is known about their structure, and hence also about function. The fine-tuned interactions between the different lipids that make up the membrane and the proteins and biologically active peptides, which have their action within or on the membrane, are especially important. Different lipids have different properties regarding their membrane-forming capacities, as well as regarding mobility, shape, size and surface charge. All of these factors influence the way that proteins and peptides interact with the membrane. We use nuclear magnetic resonance (NMR) techniques, which are uniquely suited for this research, as they provide excellent tools for determining structure, and at the same time methods that can be used to investigate dynamics on a wide time-scale. Furthermore, NMR provides methods that are used for investigating lipid dynamics and membrane order. The application focuses on two parts: 1) structure and dynamics of membrane-associated protein domains and peptides, and, 2) lipid dynamics and membrane-protein interactions.

Last updated on 2017-31-03 at 12:57